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Structural Evidence for Effectiveness of Darunavir and Two Related Antiviral Inhibitors against HIV-2 Protease

No drugs have been targeted specifically for HIV-2 infection despite the increasing prevalence worldwide. The antiviral HIV-1 protease inhibitor darunavir, and the chemically related GRL-98065 and GRL-06579A, were designed with the same chemical scaffold and different substituents at P2 and P2′ to o...

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Bibliografiske detaljer
Main Authors: Kovalevsky, Andrey Y., Louis, John M., Aniana, Annie, Ghosh, Arun K., Weber, Irene T.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597724/
https://ncbi.nlm.nih.gov/pubmed/18834890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.09.031
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