Mechanism of Dissociative Inhibition of HIV Protease and its Autoprocessing from a Precursor

Por Sayer, Jane M., Aniana, Annie, Louis, John M.
Publicado em 2012

Revealing the dimer dissociation and existence of a folded monomer of the mature HIV-2 protease

Por Louis, John M, Ishima, Rieko, Aniana, Annie, Sayer, Jane M
Publicado em 2009

Inhibition of autoprocessing of natural variants and multidrug resistant mutant precursors of HIV-1 protease by clinical inhibitors

Por Louis, John M., Aniana, Annie, Weber, Irene T., Sayer, Jane M.
Publicado em 2011

Complete dissociation of the HIV-1 gp41 ectodomain and membrane proximal regions upon phospholipid binding

Por Roche, Julien, Louis, John M., Aniana, Annie, Ghirlando, Rodolfo, Bax, Ad
Publicado no J Biomol NMR (2015)

Structural Evidence for Effectiveness of Darunavir and Two Related Antiviral Inhibitors against HIV-2 Protease

Por Kovalevsky, Andrey Y., Louis, John M., Aniana, Annie, Ghosh, Arun K., Weber, Irene T.
Publicado em 2008

Visualizing transient events in amino-terminal autoprocessing of HIV-1 protease

Por Tang, Chun, Louis, John M., Aniana, Annie, Suh, Jeong-Yong, Clore, G. Marius
Publicado em 2008

Mutations Proximal to Sites of Autoproteolysis and the α-Helix That Co-evolve under Drug Pressure Modulate the Autoprocessing and Vitality of HIV-1 Protease

Por Louis, John M., Deshmukh, Lalit, Sayer, Jane M., Aniana, Annie, Clore, G. Marius
Publicado no Biochemistry (2015)

Enhanced Stability of the Monomer Fold Correlates with Extreme Drug Resistance of HIV-1 Protease

Por Louis, John M., Tözsér, József, Roche, Julien, Matúz, Krisztina, Aniana, Annie, Sayer, Jane M.
Publicado em 2013

Insights into the Conformation of the Membrane Proximal Regions Critical to the Trimerization of the HIV-1 gp41 Ectodomain Bound to Dodecyl Phosphocholine Micelles

Por Louis, John M., Baber, James L., Ghirlando, Rodolfo, Aniana, Annie, Bax, Ad, Roche, Julien
Publicado no PLoS One (2016)

HIV-1 protease with 20 mutations exhibits extreme resistance to clinical inhibitors through coordinated structural rearrangements

Por Agniswamy, Johnson, Shen, Chen-Hsiang, Aniana, Annie, Sayer, Jane M., Louis, John M., Weber, Irene T.
Publicado em 2012

Binding of HIV-1 gp41-Directed Neutralizing and Non-Neutralizing Fragment Antibody Binding Domain (Fab) and Single Chain Variable Fragment (ScFv) Antibodies to the Ectodomain of gp...

Por Louis, John M., Aniana, Annie, Lohith, Katheryn, Sayer, Jane M., Roche, Julien, Bewley, Carole A., Clore, G. Marius
Publicado em 2014

Binding of clinical inhibitors to a model precursor of a rationally selected multidrug resistant HIV-1 protease is significantly weaker than to the released mature enzyme

Por Park, Joon H., Sayer, Jane M., Aniana, Annie, Yu, Xiaxia, Weber, Irene T., Harrison, Robert W., Louis, John M.
Publicado no Biochemistry (2016)