Binding of HIV-1 gp41-Directed Neutralizing and Non-Neutralizing Fragment Antibody Binding Domain (Fab) and Single Chain Variable Fragment (ScFv) Antibodies to the Ectodomain of gp41 in the Pre-Hairpin and Six-Helix Bundle Conformations

We previously reported a series of antibodies, in fragment antigen binding domain (Fab) formats, selected from a human non-immune phage library, directed against the internal trimeric coiled-coil of the N-heptad repeat (N-HR) of HIV-1 gp41. Broadly neutralizing antibodies from that series bind to bo...

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Main Authors: Louis, John M., Aniana, Annie, Lohith, Katheryn, Sayer, Jane M., Roche, Julien, Bewley, Carole A., Clore, G. Marius
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4126735/
https://ncbi.nlm.nih.gov/pubmed/25105806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0104683
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