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Complete dissociation of the HIV-1 gp41 ectodomain and membrane proximal regions upon phospholipid binding

The envelope glycoprotein gp41 mediates the process of membrane fusion that enables entry of the HIV-1 virus into the host cell. Strong lipid affinity of the ectodomain suggests that its heptad repeat regions play an active role in destabilizing membranes by directly binding to the lipid bilayers an...

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Publicat a:J Biomol NMR
Autors principals: Roche, Julien, Louis, John M., Aniana, Annie, Ghirlando, Rodolfo, Bax, Ad
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4398632/
https://ncbi.nlm.nih.gov/pubmed/25631354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10858-015-9900-4
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