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Enhanced Stability of the Monomer Fold Correlates with Extreme Drug Resistance of HIV-1 Protease
During treatment, mutations in HIV-1 protease (PR) are selected rapidly that confer resistance by decreasing affinity to clinical protease inhibitors (PIs). As these unique drug resistance mutations can compromise the fitness of the virus to replicate, mutations that restore conformational stability...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3888107/ https://ncbi.nlm.nih.gov/pubmed/24079831 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400962r |
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