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Solution Kinetics Measurements Suggest HIV-1 Protease Has Two Binding Sites for Darunavir and Amprenavir

Darunavir, a potent antiviral drug, showed an unusual second binding site on the HIV-1 protease dimer surface of the V32I drug resistant mutant and normal binding in the active site cavity. Kinetic analysis for wild type and mutant protease showed mixed-type competitive-uncompetitive inhibition for...

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Sonraí Bibleagrafaíochta
Main Authors: Kovalevsky, Andrey Y., Ghosh, Arun K., Weber, Irene T.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2008
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2771923/
https://ncbi.nlm.nih.gov/pubmed/18808097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800283k
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