Caught in the Act: 1.5 Å Resolution Crystal Structures of the HIV-1 Protease and the I54V Mutant Reveal a Tetrahedral Reaction Intermediate

Lignende værker

• Ultra-high Resolution Crystal Structure of HIV-1 Protease Mutant Reveals Two Binding Sites for Clinical Inhibitor TMC114
  af: Kovalevsky, Andrey Y., et al.
  Udgivet: (2006)
• Effect of Flap Mutations on Structure of HIV-1 Protease and Inhibition by Saquinavir and Darunavir
  af: Liu, Fengling, et al.
  Udgivet: (2008)
• Capturing the Reaction Pathway in Near-Atomic Resolution Crystal Structures of HIV-1 Protease
  af: Shen, Chen-Hsiang, et al.
  Udgivet: (2012)
• Observation of a tetrahedral reaction intermediate in the HIV-1 protease–substrate complex
  af: Kumar, Mukesh, et al.
  Udgivet: (2005)
• Visualizing Tetrahedral Oxyanion Bound in HIV-1 Protease Using Neutrons: Implications for the Catalytic Mechanism and Drug Design
  af: Kumar, Mukesh, et al.
  Udgivet: (2020)