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Observation of a tetrahedral reaction intermediate in the HIV-1 protease–substrate complex

HIV-1 protease is an effective target for the design of drugs against AIDS. To help this process of drug design, three-dimensional structures have been determined of complexes between HIV-1 protease and a variety of transition-state analogue inhibitors. The true transition state, however, has not be...

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Bibliografiske detaljer
Main Authors: Kumar, Mukesh, Prashar, Vishal, Mahale, Smita, Hosur, Madhusoodan V.
Format: Artigo
Sprog:Inglês
Udgivet: Portland Press Ltd. 2005
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1175113/
https://ncbi.nlm.nih.gov/pubmed/15794743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20041804
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