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Observation of a tetrahedral reaction intermediate in the HIV-1 protease–substrate complex
HIV-1 protease is an effective target for the design of drugs against AIDS. To help this process of drug design, three-dimensional structures have been determined of complexes between HIV-1 protease and a variety of transition-state analogue inhibitors. The true transition state, however, has not be...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Portland Press Ltd.
2005
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1175113/ https://ncbi.nlm.nih.gov/pubmed/15794743 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20041804 |
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