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Crystal structure of HIV-1 protease in situ product complex and observation of a low-barrier hydrogen bond between catalytic aspartates

HIV-1 protease is an effective target for designing drugs against AIDS, and structural information about the true transition state and the correct mechanism can provide important inputs. We present here the three-dimensional structure of a bi-product complex between HIV-1 protease and the two cleava...

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Autori principali: Das, Amit, Prashar, Vishal, Mahale, Smita, Serre, L., Ferrer, J.-L., Hosur, M. V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1693685/
https://ncbi.nlm.nih.gov/pubmed/17116869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0605809103
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