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Catalytic Water Co-Existing with a Product Peptide in the Active Site of HIV-1 Protease Revealed by X-Ray Structure Analysis

BACKGROUND: It is known that HIV-1 protease is an important target for design of antiviral compounds in the treatment of Acquired Immuno Deficiency Syndrome (AIDS). In this context, understanding the catalytic mechanism of the enzyme is of crucial importance as transition state structure directs inh...

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Bibliografiske detaljer
Main Authors: Prashar, Vishal, Bihani, Subhash, Das, Amit, Ferrer, Jean-Luc, Hosur, Madhusoodan
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775671/
https://ncbi.nlm.nih.gov/pubmed/19924250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007860
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