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Capturing the Reaction Pathway in Near-Atomic Resolution Crystal Structures of HIV-1 Protease
Snapshots of three consecutive steps in the proteolytic reaction of HIV-1 protease (PR) were obtained in crystal structures at resolutions of 1.2 to 1.4 Å. Structures of wild type protease and two mutants (PR(V32I) and PR(I47V)) with substitutions of V32I and I47V, which are common in drug resistanc...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3476052/ https://ncbi.nlm.nih.gov/pubmed/22963370 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi3008092 |
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