Ultra-high Resolution Crystal Structure of HIV-1 Protease Mutant Reveals Two Binding Sites for Clinical Inhibitor TMC114

TMC114 (darunavir) is a promising clinical inhibitor of HIV-1 protease (PR) for treatment of drug resistant HIV/AIDS. We report the ultra-high 0.84Å resolution crystal structure of the TMC114 complex with PR containing the drug resistant mutation V32I (PR(V32I)), and the 1.22 Å resolution structure...

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Bibliographic Details
Main Authors: Kovalevsky, Andrey Y., Liu, Fengling, Leshchenko, Sofiya, Ghosh, Arun K., Louis, John M., Harrison, Robert W., Weber, Irene T.
Format: Artigo
Language:Inglês
Published: 2006
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1781337/
https://ncbi.nlm.nih.gov/pubmed/16962136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2006.08.007
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