The role of cystic fibrosis transmembrane conductance regulator phenylalanine 508 side chain in ion channel gating

Cystic fibrosis transmembrane conductance regulator (CFTR) is an ion channel employing the ABC transporter structural motif. Deletion of a single residue (Phe508) in the first nucleotide-binding domain (NBD1), which occurs in most patients with cystic fibrosis, impairs both maturation and function o...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Cui, Liying, Aleksandrov, Luba, Hou, Yue-Xian, Gentzsch, Martina, Chen, Jey-Hsin, Riordan, John R, Aleksandrov, Andrei A
Format: Artigo
Langue:Inglês
Publié: Blackwell Science Inc 2006
Sujets:
Molecular and Genomic
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1779664/
https://ncbi.nlm.nih.gov/pubmed/16484308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2005.099457
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