The role of cystic fibrosis transmembrane conductance regulator phenylalanine 508 side chain in ion channel gating

Cystic fibrosis transmembrane conductance regulator (CFTR) is an ion channel employing the ABC transporter structural motif. Deletion of a single residue (Phe508) in the first nucleotide-binding domain (NBD1), which occurs in most patients with cystic fibrosis, impairs both maturation and function o...

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Detalhes bibliográficos
Main Authors: Cui, Liying, Aleksandrov, Luba, Hou, Yue-Xian, Gentzsch, Martina, Chen, Jey-Hsin, Riordan, John R, Aleksandrov, Andrei A
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2006
Assuntos:
Molecular and Genomic
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1779664/
https://ncbi.nlm.nih.gov/pubmed/16484308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2005.099457
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