A catalytic switch and the conversion of streptokinase to a fibrin-targeted plasminogen activator

Plasminogen (Pg) activators such as streptokinase (SK) save lives by generating plasmin to dissolve blood clots. Some believe that the unique ability of SK to activate Pg in the absence of fibrin limits its therapeutic utility. We have found that SK contains an unusual NH(2)-terminal “catalytic swit...

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Autors principals: Reed, Guy L., Houng, Aiilyan K., Liu, Lin, Parhami-Seren, Behnaz, Matsueda, Lee H., Wang, Shunguang, Hedstrom, Lizbeth
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 1999
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC17701/
https://ncbi.nlm.nih.gov/pubmed/10430864
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