A catalytic switch and the conversion of streptokinase to a fibrin-targeted plasminogen activator

Plasminogen (Pg) activators such as streptokinase (SK) save lives by generating plasmin to dissolve blood clots. Some believe that the unique ability of SK to activate Pg in the absence of fibrin limits its therapeutic utility. We have found that SK contains an unusual NH(2)-terminal “catalytic swit...

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Xehetasun bibliografikoak
Egile Nagusiak: Reed, Guy L., Houng, Aiilyan K., Liu, Lin, Parhami-Seren, Behnaz, Matsueda, Lee H., Wang, Shunguang, Hedstrom, Lizbeth
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The National Academy of Sciences 1999
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC17701/
https://ncbi.nlm.nih.gov/pubmed/10430864
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