A catalytic switch and the conversion of streptokinase to a fibrin-targeted plasminogen activator

Plasminogen (Pg) activators such as streptokinase (SK) save lives by generating plasmin to dissolve blood clots. Some believe that the unique ability of SK to activate Pg in the absence of fibrin limits its therapeutic utility. We have found that SK contains an unusual NH(2)-terminal “catalytic swit...

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Bibliografiske detaljer
Main Authors: Reed, Guy L., Houng, Aiilyan K., Liu, Lin, Parhami-Seren, Behnaz, Matsueda, Lee H., Wang, Shunguang, Hedstrom, Lizbeth
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 1999
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC17701/
https://ncbi.nlm.nih.gov/pubmed/10430864
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