Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm

Mutational inactivation of the adenomatous polyposis coli (APC) tumor suppressor initiates most hereditary and sporadic colon carcinomas. Although APC protein is located in both the cytoplasm and the nucleus, the protein domains required to maintain a predominantly cytoplasmic localization are unkno...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Neufeld, Kristi L., Nix, David A., Bogerd, Hal, Kang, Yibin, Beckerle, Mary C., Cullen, Bryan R., White, Raymond L.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17298/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11035805/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.220401797
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