Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm

Mutational inactivation of the adenomatous polyposis coli (APC) tumor suppressor initiates most hereditary and sporadic colon carcinomas. Although APC protein is located in both the cytoplasm and the nucleus, the protein domains required to maintain a predominantly cytoplasmic localization are unkno...

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הוצא לאור ב:	Proc Natl Acad Sci U S A
Principais autores:	Neufeld, Kristi L., Nix, David A., Bogerd, Hal, Kang, Yibin, Beckerle, Mary C., Cullen, Bryan R., White, Raymond L.
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	National Academy of Sciences 2000
נושאים:	Biological Sciences
גישה מקוונת:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17298/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11035805/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.220401797
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