Cell Density and Phosphorylation Control the Subcellular Localization of Adenomatous Polyposis Coli Protein

Loss of functional adenomatous polyposis coli protein (APC) leads to uncontrolled proliferation of colonic epithelial cells, as evidenced by polyp formation, a prelude to carcinogenesis. As a tumor suppressor, APC targets the oncogene β-catenin for proteasome-mediated cytoplasmic degradation. Recent...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Zhang, Fang, White, Raymond L., Neufeld, Kristi L.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2001
Assuntos:	Nucleocytoplasmic Communication
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC99979/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11689703/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.23.8143-8156.2001
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