Cell Density and Phosphorylation Control the Subcellular Localization of Adenomatous Polyposis Coli Protein

Loss of functional adenomatous polyposis coli protein (APC) leads to uncontrolled proliferation of colonic epithelial cells, as evidenced by polyp formation, a prelude to carcinogenesis. As a tumor suppressor, APC targets the oncogene β-catenin for proteasome-mediated cytoplasmic degradation. Recent...

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Bibliografiske detaljer
Main Authors: Zhang, Fang, White, Raymond L., Neufeld, Kristi L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2001
Fag:
Nucleocytoplasmic Communication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC99979/
https://ncbi.nlm.nih.gov/pubmed/11689703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.23.8143-8156.2001
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