Cell Density and Phosphorylation Control the Subcellular Localization of Adenomatous Polyposis Coli Protein
Loss of functional adenomatous polyposis coli protein (APC) leads to uncontrolled proliferation of colonic epithelial cells, as evidenced by polyp formation, a prelude to carcinogenesis. As a tumor suppressor, APC targets the oncogene β-catenin for proteasome-mediated cytoplasmic degradation. Recent...
שמור ב:
| הוצא לאור ב: | Mol Cell Biol |
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| Principais autores: | , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Taylor & Francis
2001
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC99979/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11689703/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.23.8143-8156.2001 |
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