Cell Density and Phosphorylation Control the Subcellular Localization of Adenomatous Polyposis Coli Protein

Loss of functional adenomatous polyposis coli protein (APC) leads to uncontrolled proliferation of colonic epithelial cells, as evidenced by polyp formation, a prelude to carcinogenesis. As a tumor suppressor, APC targets the oncogene β-catenin for proteasome-mediated cytoplasmic degradation. Recent...

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Библиографические подробности

Опубликовано в::	Mol Cell Biol
Главные авторы:	Zhang, Fang, White, Raymond L., Neufeld, Kristi L.
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Taylor & Francis 2001
Предметы:	Nucleocytoplasmic Communication
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC99979/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11689703/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.23.8143-8156.2001
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