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Mechanisms of genotoxin-induced transcription and hypermutation in p53
It is widely assumed that genotoxin-induced damage (e.g., G-to-T transversions) to the tumor suppressor gene, p53, is a direct cause of cancer. However, genotoxins also induce the stress response, which upregulates p53 transcription and the formation of secondary structures from ssDNA. Since unpaire...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BioMed Central
2006
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1702552/ https://ncbi.nlm.nih.gov/pubmed/17140443 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2867-6-27 |
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