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II. Correlations between secondary structure stability and mutation frequency during somatic hypermutation

The role of secondary structures and base mutability at different levels of transcription and supercoiling is analyzed in variable region antibody genes VH5, VH94 and VH186.2. The data are consistent with a model of somatic hypermutation in which increasing levels of transcription and secondary stru...

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Detalhes bibliográficos
Main Authors: Wright, Barbara E., Schmidt, Karen H., Davis, Nick, Hunt, Aaron T., Minnick, Michael F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2529022/
https://ncbi.nlm.nih.gov/pubmed/18584870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2008.05.012
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