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VH gene transcription creates stabilized secondary structures for coordinated mutagenesis during somatic hypermutation
During the adaptive immune response, antigen challenge triggers a million-fold increase in mutation rates in the variable region antibody genes. The frequency of mutation is causally and directly linked to transcription, which provides ssDNA and drives supercoiling that stabilizes secondary structur...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2570340/ https://ncbi.nlm.nih.gov/pubmed/18585784 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2008.02.030 |
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