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The roles of transcription and genotoxins underlying p53 mutagenesis in vivo
Transcription drives supercoiling which forms and stabilizes single-stranded (ss) DNA secondary structures with loops exposing G and C bases that are intrinsically mutable and vulnerable to non-enzymatic hydrolytic reactions. Since many studies in prokaryotes have shown direct correlations between t...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3179427/ https://ncbi.nlm.nih.gov/pubmed/21803733 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgr177 |
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