Excision repair is required for genotoxin-induced mutagenesis in mammalian cells

Certain hexavalent chromium [Cr(VI)] compounds are human lung carcinogens. Although much is known about Cr-induced DNA damage, very little is known about mechanisms of Cr(VI) mutagenesis and the role that DNA repair plays in this process. Our goal was to investigate the role of excision repair (ER)...

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Main Authors: Brooks, Bradford, O'Brien, Travis J., Ceryak, Susan, Wise, John Pierce, Wise, Sandra S., DeFabo, Edward, Patierno, Steven R.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2008
Teme:
Carcinogenesis
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2902384/
https://ncbi.nlm.nih.gov/pubmed/18332048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgn058
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