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Polo-like kinase 1 enhances survival and mutagenesis after genotoxic stress in normal cells through cell cycle checkpoint bypass

Polo-like kinase 1 (Plk1) is a key regulator of mitosis. Aberrant Plk1 activity is found in tumors, but little is known regarding its role in the DNA damage response of normal cells and its potential contribution to the early stages of carcinogenesis. Inappropriate survival signaling after DNA damag...

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Bibliografske podrobnosti
Main Authors: Chun, Gina, Bae, Dongsoon, Nickens, Kristen, O’Brien, Travis J., Patierno, Steven R., Ceryak, Susan
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2864408/
https://ncbi.nlm.nih.gov/pubmed/20089605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgq014
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