AKT1 mediates bypass of the G(1)/S checkpoint after genotoxic stress in normal human cells

Certain forms of hexavalent chromium [Cr(VI)] are human carcinogens. Our recent work has shown that a broad range protein tyrosine phosphatase (PTP) inhibitor, sodium orthovanadate (SOV), abrogated both Cr(VI)-induced growth arrest and clonogenic lethality. Notably, SOV enhanced Cr(VI) mutation freq...

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Hauptverfasser: Lal, Madhu A., Bae, Dongsoon, Camilli, Tura C., Patierno, Steven R., Ceryak, Susan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3753188/
https://ncbi.nlm.nih.gov/pubmed/19377290
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