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Evolution of coordinated mutagenesis and somatic hypermutation in VH5

The VH5 human antibody gene was analyzed using a computer program (mfg) which simulates transcription, to better understand transcription-driven mutagenesis events that occur during “phase 1” of somatic hypermutation. Results show that the great majority of mutations in the non-transcribed strand oc...

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Bibliografski detalji
Glavni autori: Wright, Barbara E., Schmidt, Karen H., Hunt, Aaron T., Reschke, Dennis K., Minnick, Michael F.
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3235918/
https://ncbi.nlm.nih.gov/pubmed/22056943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2011.10.001
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