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Directed evolution of mammalian anti-apoptosis proteins by somatic hypermutation
Recently, researchers have created novel fluorescent proteins by harnessing the somatic hypermutation ability of B cells. In this study, we examined if this approach could be used to evolve a non-fluorescent protein, namely the anti-apoptosis protein Bcl-x(L), using the Ramos B-cell line. After demo...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3276308/ https://ncbi.nlm.nih.gov/pubmed/22160868 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzr052 |
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