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Mechanisms of genotoxin-induced transcription and hypermutation in p53

It is widely assumed that genotoxin-induced damage (e.g., G-to-T transversions) to the tumor suppressor gene, p53, is a direct cause of cancer. However, genotoxins also induce the stress response, which upregulates p53 transcription and the formation of secondary structures from ssDNA. Since unpaire...

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Detalhes bibliográficos
Main Authors: Wright, Barbara, Reimers, Jacqueline, Schmidt, Karen, Burkala, Evan, Davis, Nick, Wei, Ping
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1702552/
https://ncbi.nlm.nih.gov/pubmed/17140443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2867-6-27
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