Essential Role of Phospholipase Cγ2 in Early B-Cell Development and Myc-Mediated Lymphomagenesis

Phospholipase Cγ2 (PLCγ2) is a critical signaling effector of the B-cell receptor (BCR). Here we show that PLCγ2 deficiency impedes early B-cell development, resulting in an increase of B220(+) CD43(+) BP-1(+) CD24(hi) pre-BCR(+) large pre-B cells. PLCγ2 deficiency impairs pre-BCR-mediated functions...

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Bibliografiske detaljer
Main Authors: Wen, Renren, Chen, Yuhong, Bai, Li, Fu, Guoping, Schuman, James, Dai, Xuezhi, Zeng, Hu, Yang, Chunying, Stephan, Robert P., Cleveland, John L., Wang, Demin
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2006
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698523/
https://ncbi.nlm.nih.gov/pubmed/17030619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00839-06
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