Distinct Roles of Phosphoinositide-3 Kinase and Phospholipase Cγ2 in B-Cell Receptor-Mediated Signal Transduction

During B-cell receptor (BCR) signaling, phosphoinositide-3 kinase (PI3K) is thought to function upstream of phospholipase Cγ2 (PLCγ2). PLCγ2 deficiency specifically impedes transitional type 2 (T2) to follicular (FO) mature B-cell transition. Here, we demonstrate that PI3K deficiency specifically im...

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Autores principales: Dai, Xuezhi, Chen, Yuhong, Schuman, James, Hua, Zichun, Adamson, John W., Wen, Renren, Wang, Demin
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2006
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1317611/
https://ncbi.nlm.nih.gov/pubmed/16354682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.1.88-99.2006
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