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Essential Role of Phospholipase Cγ2 in Early B-Cell Development and Myc-Mediated Lymphomagenesis
Phospholipase Cγ2 (PLCγ2) is a critical signaling effector of the B-cell receptor (BCR). Here we show that PLCγ2 deficiency impedes early B-cell development, resulting in an increase of B220(+) CD43(+) BP-1(+) CD24(hi) pre-BCR(+) large pre-B cells. PLCγ2 deficiency impairs pre-BCR-mediated functions...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1698523/ https://ncbi.nlm.nih.gov/pubmed/17030619 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00839-06 |
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