Phospholipase Cγ1 is essential for T cell development, activation, and tolerance

Phospholipase Cγ1 (PLCγ1) is an important signaling effector of T cell receptor (TCR). To investigate the role of PLCγ1 in T cell biology, we generated and examined mice with T cell–specific deletion of PLCγ1. We demonstrate that PLCγ1 deficiency affects positive and negative selection, significantl...

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Main Authors: Fu, Guoping, Chen, Yuhong, Yu, Mei, Podd, Andy, Schuman, James, He, Yinghong, Di, Lie, Yassai, Maryam, Haribhai, Dipica, North, Paula E., Gorski, Jack, Williams, Calvin B., Wang, Demin, Wen, Renren
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2010
Teme:
Brief Definitive Report
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2822604/
https://ncbi.nlm.nih.gov/pubmed/20123962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20090880
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