Phospholipase Cγ2 Contributes to Light-Chain Gene Activation and Receptor Editing

Phospholipase Cγ2 (PLCγ2) is critical for pre-B-cell receptor (pre-BCR) and BCR signaling. Current studies discovered that PLCγ2-deficient mice had reduced immunoglobulin λ (Igλ) light-chain usage throughout B-cell maturation stages, including transitional type 1 (T1), transitional type 2 (T2), and...

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Bibliographic Details
Main Authors: Bai, Li, Chen, Yuhong, He, Yinghong, Dai, Xuezhi, Lin, Xueyan, Wen, Renren, Wang, Demin
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2007
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1952164/
https://ncbi.nlm.nih.gov/pubmed/17591700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.02273-06
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