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Consequences of Copper Accumulation in the Livers of the Atp7b(−/−) (Wilson Disease Gene) Knockout Mice
Wilson disease is a severe genetic disorder associated with intracellular copper overload. The affected gene, ATP7B, has been identified, but the molecular events leading to Wilson disease remain poorly understood. Here, we demonstrate that genetically engineered Atp7b(−/−) mice represent a valuable...
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| Auteurs principaux: | , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Investigative Pathology
2006
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1606493/ https://ncbi.nlm.nih.gov/pubmed/16436657 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.050312 |
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