Consequences of Copper Accumulation in the Livers of the Atp7b(−/−) (Wilson Disease Gene) Knockout Mice

Wilson disease is a severe genetic disorder associated with intracellular copper overload. The affected gene, ATP7B, has been identified, but the molecular events leading to Wilson disease remain poorly understood. Here, we demonstrate that genetically engineered Atp7b(−/−) mice represent a valuable...

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Main Authors: Huster, Dominik, Finegold, Milton J., Morgan, Clinton T., Burkhead, Jason L., Nixon, Randal, Vanderwerf, Scott M., Gilliam, Conrad T., Lutsenko, Svetlana
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Investigative Pathology 2006
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Original Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1606493/
https://ncbi.nlm.nih.gov/pubmed/16436657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.050312
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