Wilson Disease at a Single Cell Level: INTRACELLULAR COPPER TRAFFICKING ACTIVATES COMPARTMENT-SPECIFIC RESPONSES IN HEPATOCYTES

Wilson disease (WD) is a severe hepato-neurologic disorder that affects primarily children and young adults. WD is caused by mutations in ATP7B and subsequent copper overload. However, copper levels alone do not predict severity of the disease. We demonstrate that temporal and spatial distribution o...

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Bibliografiske detaljer
Main Authors: Ralle, Martina, Huster, Dominik, Vogt, Stefan, Schirrmeister, Wiebke, Burkhead, Jason L., Capps, Tony R., Gray, Lawrence, Lai, Barry, Maryon, Edward, Lutsenko, Svetlana
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Molecular Bases of Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2945580/
https://ncbi.nlm.nih.gov/pubmed/20647314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.114447
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