Wilson Disease at a Single Cell Level: INTRACELLULAR COPPER TRAFFICKING ACTIVATES COMPARTMENT-SPECIFIC RESPONSES IN HEPATOCYTES

Wilson disease (WD) is a severe hepato-neurologic disorder that affects primarily children and young adults. WD is caused by mutations in ATP7B and subsequent copper overload. However, copper levels alone do not predict severity of the disease. We demonstrate that temporal and spatial distribution o...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Ralle, Martina, Huster, Dominik, Vogt, Stefan, Schirrmeister, Wiebke, Burkhead, Jason L., Capps, Tony R., Gray, Lawrence, Lai, Barry, Maryon, Edward, Lutsenko, Svetlana
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2010
Sujets:
Molecular Bases of Disease
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2945580/
https://ncbi.nlm.nih.gov/pubmed/20647314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.114447
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires