Consequences of Copper Accumulation in the Livers of the Atp7b(−/−) (Wilson Disease Gene) Knockout Mice

Wilson disease is a severe genetic disorder associated with intracellular copper overload. The affected gene, ATP7B, has been identified, but the molecular events leading to Wilson disease remain poorly understood. Here, we demonstrate that genetically engineered Atp7b(−/−) mice represent a valuable...

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Bibliographic Details
Main Authors: Huster, Dominik, Finegold, Milton J., Morgan, Clinton T., Burkhead, Jason L., Nixon, Randal, Vanderwerf, Scott M., Gilliam, Conrad T., Lutsenko, Svetlana
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2006
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Original Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1606493/
https://ncbi.nlm.nih.gov/pubmed/16436657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.050312
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