Consequences of Copper Accumulation in the Livers of the Atp7b(−/−) (Wilson Disease Gene) Knockout Mice

Wilson disease is a severe genetic disorder associated with intracellular copper overload. The affected gene, ATP7B, has been identified, but the molecular events leading to Wilson disease remain poorly understood. Here, we demonstrate that genetically engineered Atp7b(−/−) mice represent a valuable...

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Bibliographische Detailangaben
Hauptverfasser: Huster, Dominik, Finegold, Milton J., Morgan, Clinton T., Burkhead, Jason L., Nixon, Randal, Vanderwerf, Scott M., Gilliam, Conrad T., Lutsenko, Svetlana
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2006
Schlagworte:
Original Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1606493/
https://ncbi.nlm.nih.gov/pubmed/16436657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.050312
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