SB-656104-A, a novel selective 5-HT(7) receptor antagonist, modulates REM sleep in rats

1. (6-((R)-2-{2-[4-(4-Chloro-phenoxy)-piperidin-1-yl]-ethyl}-pyrrolidine-1-sulphonyl)-1H-indole hydrochloride) (SB-656104-A), a novel 5-hydroxytryptamine (5-HT(7)) receptor antagonist, potently inhibited [(3)H]-SB-269970 binding to the human cloned 5-HT(7(a)) (pK(i) 8.7±0.1) and 5-HT(7(b)) (pK(i) 8....

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Hlavní autoři: Thomas, David R, Melotto, Sergio, Massagrande, Mario, Gribble, Andrew D, Jeffrey, Phillip, Stevens, Alexander J, Deeks, Nigel J, Eddershaw, Peter J, Fenwick, Susan H, Riley, Graham, Stean, Tania, Scott, Claire M, Hill, Matthew J, Middlemiss, Derek N, Hagan, Jim J, Price, Gary W, Forbes, Ian T
Médium: Artigo
Jazyk:Inglês
Vydáno: 2003
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Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573887/
https://ncbi.nlm.nih.gov/pubmed/12812993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705290
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