[(3)H]-SB-269970 – A selective antagonist radioligand for 5-HT(7) receptors

1. Binding of the 5-HT(7) receptor antagonist radioligand [(3)H]-SB-269970 to human 5-HT(7(a)) receptors expressed in HEK293 cell membranes (h5-HT(7(a))/293) and to guinea-pig cerebral cortex membranes, was characterized and compared with [(3)H]-5-CT binding. 2. [(3)H]-SB-269970 (1 nM) showed full a...

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Sonraí Bibleagrafaíochta
Main Authors: Thomas, David R, Atkinson, Peter J, Ho, Michael, Bromidge, Steven M, Lovell, Peter J, Villani, Anthony J, Hagan, Jim J, Middlemiss, Derek N, Price, Gary W
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2000
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Papers
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572078/
https://ncbi.nlm.nih.gov/pubmed/10807680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703318
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