SB-656104-A, a novel selective 5-HT(7) receptor antagonist, modulates REM sleep in rats

1. (6-((R)-2-{2-[4-(4-Chloro-phenoxy)-piperidin-1-yl]-ethyl}-pyrrolidine-1-sulphonyl)-1H-indole hydrochloride) (SB-656104-A), a novel 5-hydroxytryptamine (5-HT(7)) receptor antagonist, potently inhibited [(3)H]-SB-269970 binding to the human cloned 5-HT(7(a)) (pK(i) 8.7±0.1) and 5-HT(7(b)) (pK(i) 8....

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Bibliografiset tiedot
Päätekijät: Thomas, David R, Melotto, Sergio, Massagrande, Mario, Gribble, Andrew D, Jeffrey, Phillip, Stevens, Alexander J, Deeks, Nigel J, Eddershaw, Peter J, Fenwick, Susan H, Riley, Graham, Stean, Tania, Scott, Claire M, Hill, Matthew J, Middlemiss, Derek N, Hagan, Jim J, Price, Gary W, Forbes, Ian T
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2003
Aiheet:
Papers
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573887/
https://ncbi.nlm.nih.gov/pubmed/12812993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705290
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