SB-656104-A, a novel selective 5-HT(7) receptor antagonist, modulates REM sleep in rats

1. (6-((R)-2-{2-[4-(4-Chloro-phenoxy)-piperidin-1-yl]-ethyl}-pyrrolidine-1-sulphonyl)-1H-indole hydrochloride) (SB-656104-A), a novel 5-hydroxytryptamine (5-HT(7)) receptor antagonist, potently inhibited [(3)H]-SB-269970 binding to the human cloned 5-HT(7(a)) (pK(i) 8.7±0.1) and 5-HT(7(b)) (pK(i) 8....

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Detalhes bibliográficos
Main Authors: Thomas, David R, Melotto, Sergio, Massagrande, Mario, Gribble, Andrew D, Jeffrey, Phillip, Stevens, Alexander J, Deeks, Nigel J, Eddershaw, Peter J, Fenwick, Susan H, Riley, Graham, Stean, Tania, Scott, Claire M, Hill, Matthew J, Middlemiss, Derek N, Hagan, Jim J, Price, Gary W, Forbes, Ian T
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
Assuntos:
Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573887/
https://ncbi.nlm.nih.gov/pubmed/12812993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705290
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