Characterization of SB-271046: A potent, selective and orally active 5-HT(6) receptor antagonist

1. SB-271046, potently displaced [(3)H]-LSD and [(125)I]-SB-258585 from human 5-HT(6) receptors recombinantly expressed in HeLa cells in vitro (pK(i) 8.92 and 9.09 respectively). SB-271046 also displaced [(125)I]-SB-258585 from human caudate putamen and rat and pig striatum membranes (pK(i) 8.81, 9....

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Bibliographische Detailangaben
Hauptverfasser: Routledge, Carol, Bromidge, Steven M, Moss, Stephen F, Price, Gary W, Hirst, Warren, Newman, Helen, Riley, Graham, Gager, Tracey, Stean, Tania, Upton, Neil, Clarke, Stephen E, Brown, Anthony M, Middlemiss, Derek N
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2000
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Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572216/
https://ncbi.nlm.nih.gov/pubmed/10928964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703457
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