Characterization of [(125)I]-SB-258585 binding to human recombinant and native 5-HT(6) receptors in rat, pig and human brain tissue

1. SB-258585 (4-Iodo-N-[4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]-benzenesulphonamide) is a high affinity ligand at 5-HT(6) receptors. It displays over 100 fold selectivity for the 5-HT(6) receptor over all other 5-HT receptors tested so far. SB-258585 has been radiolabelled, to high specific ac...

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Autors principals: Hirst, Warren D, Minton, Jayne A L, Bromidge, Steven M, Moss, Stephen F, Latter, Alison J, Riley, Graham, Routledge, Carol, Middlemiss, Derek N, Price, Gary W
Format: Artigo
Idioma:Inglês
Publicat: 2000
Matèries:
Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572217/
https://ncbi.nlm.nih.gov/pubmed/10928963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703458
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