Characterization of SB-269970-A, a selective 5-HT(7) receptor antagonist

1. The novel 5-HT(7) receptor antagonist, SB-269970-A, potently displaced [(3)H]-5-CT from human 5-HT(7(a)) (pK(i) 8.9±0.1) and 5-HT(7) receptors in guinea-pig cortex (pK(i) 8.3±0.2). 2. 5-CT stimulated adenylyl cyclase activity in 5-HT(7(a))/HEK293 membranes (pEC(50) 7.5±0.1) and SB-269970-A (0.03–...

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Bibliographische Detailangaben
Hauptverfasser: Hagan, Jim J, Price, Gary W, Jeffrey, Phillip, Deeks, Nigel J, Stean, Tania, Piper, David, Smith, Martin I, Upton, Neil, Medhurst, Andrew D, Middlemiss, Derek N, Riley, Graham J, Lovell, Peter J, Bromidge, Steven M, Thomas, David R
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2000
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Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572114/
https://ncbi.nlm.nih.gov/pubmed/10821781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703357
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