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Characterization of SB-269970-A, a selective 5-HT(7) receptor antagonist

1. The novel 5-HT(7) receptor antagonist, SB-269970-A, potently displaced [(3)H]-5-CT from human 5-HT(7(a)) (pK(i) 8.9±0.1) and 5-HT(7) receptors in guinea-pig cortex (pK(i) 8.3±0.2). 2. 5-CT stimulated adenylyl cyclase activity in 5-HT(7(a))/HEK293 membranes (pEC(50) 7.5±0.1) and SB-269970-A (0.03–...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Hagan, Jim J, Price, Gary W, Jeffrey, Phillip, Deeks, Nigel J, Stean, Tania, Piper, David, Smith, Martin I, Upton, Neil, Medhurst, Andrew D, Middlemiss, Derek N, Riley, Graham J, Lovell, Peter J, Bromidge, Steven M, Thomas, David R
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2000
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572114/
https://ncbi.nlm.nih.gov/pubmed/10821781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703357
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