Increased islet apoptosis in Pdx1(+/–) mice

Mice with 50% Pdx1, a homeobox gene critical for pancreatic development, had worsening glucose tolerance with age and reduced insulin release in response to glucose, KCl, and arginine from the perfused pancreas. Surprisingly, insulin secretion in perifusion or static incubation experiments in respon...

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Bibliografiske detaljer
Main Authors: Johnson, James D., Ahmed, Noreen T., Luciani, Dan S., Han, Zhiqiang, Tran, Hung, Fujita, Jun, Misler, Stanley, Edlund, Helena, Polonsky, Kenneth S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2003
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC152933/
https://ncbi.nlm.nih.gov/pubmed/12697734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200316537
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